Since the beginning of philosophy, philosophers have sought objective knowledge: knowledge of things whose existence does not depend on one's conceiving of them. This book uses lessons from debates over objective knowledge to characterize the kinds of reasons pertinent to philosophical and other theoretical views. It argues that we cannot meet skeptics' typical demands for nonquestion-begging support for claims to objective truth, and that therefore we should not regard our supporting reasons as resistant to skeptical challenges. One key lesson is (...) that a constructive, explanatory approach to philosophy must change the subject from skeptic-resistant reasons to perspectival reasons arising from variable semantic commitments and instrumental, purpose-relative considerations. The book lays foundations for such a reorientation of philosophy, treating fundamental methodological issues in ontology, epistemology, the theory of meaning, the philosophy of mind, and the theory of practical rationality. It explains how certain perennial debates in philosophy rest not on genuine disagreement, but on conceptual diversity: talk about different matters. The book shows how acknowledgment of conceptual diversity can resolve a range of traditional disputes in philosophy. It also explains why philosophers need not anchor their discipline in the physicalism of the natural sciences. (shrink)

In this book, Paul K. Moser offers a new approach to religious experience and the kind of evidence it provides. Here, he explains the nature of theistic and non-theistic experience in relation to the meaning of human life and its underlying evidence, with special attention given to the perspectives of Tolstoy, Buddha, Confucius, Krishna, Moses, the apostle Paul, and Muhammad. Among the many topics explored in this timely volume are: religious experience characterized in a unifying conception; religious experience (...) naturalized relative to science; religious experience psychologized in merely psychological phenomena; and religious experience cognized relative to potential defeaters from evil, divine hiddenness, and religious diversity. Understanding Religious Experience will benefit those interested in the nature of religion and can be used in relevant courses in religious studies, philosophy, theology, Biblical studies, and the history of religion. (shrink)

This book is an accessible introduction to contemporary epistemology, the theory of knowledge. It introduces traditional topics in epistemology within the context of contemporary debates about the definition, sources, and limits of human knowledge. Rich in examples and written in an engaging style, it explains the field while avoiding technical detail. It relates epistemology to work in cognitive science and defends a plausible version of explanationism regarding epistemological method.

Genomic research—including whole genome sequencing and whole exome sequencing—has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research—historically referred to as “incidental findings”—has generated considerable discussion as to how this information should be handled—that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of “the procedures to be followed” in (...) the research as part of the informed consent process. It seems reasonable to assume—and indeed, many commentators have concluded—that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in‐depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants’ decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. (shrink)

Paul Moser's book defends what has been an unfashionable view in recent epistemology: the foundationalist account of knowledge and justification. Since the time of Plato philosophers have wondered what exactly knowledge is. This book develops a new account of perceptual knowledge which specifies the exact sense in which knowledge has foundations. The author argues that experiential foundations are indeed essential to perceptual knowledge, and he explains what knowledge requires beyond justified true beliefs. In challenging prominent sceptical claims that we (...) have no justified beliefs about the external world, the book outlines a theory of rational belief. (shrink)

Paul Moser's book defends what has been an unfashionable view in recent epistemology: the foundationalist account of knowledge and justification. Since the time of Plato philosophers have wondered what exactly knowledge is. This book develops a new account of perceptual knowledge which specifies the exact sense in which knowledge has foundations. The author argues that experiential foundations are indeed essential to perceptual knowledge, and he explains what knowledge requires beyond justified true beliefs. In challenging prominent sceptical claims that we (...) have no justified beliefs about the external world, the book outlines a theory of rational belief. (shrink)

We shall formulate an analysis of the ordinary notion of intentional action that clarifies a commonsense distinction between intentional and nonintentional action. Our analysis will build on some typically neglected considerations about relations between lucky action and intentional action. It will highlight the often- overlooked role of evidential considerations in intentional action, thus identifying the key role of certain epistemological considerations in action theory. We shall also explain why some vagueness is indispensable in a characterization of intentional action as ordinarily (...) understood. (shrink)

Johnson and Stricker published an opinion piece in the Journal of Medical Ethics presenting their perspective on the 2008 agreement between the Infectious Diseases Society of America (IDSA) and the Connecticut Attorney General with regard to the 2006 IDSA treatment guideline for Lyme disease. Their writings indicate that these authors hold unconventional views of a relatively common tick-transmitted bacterial infection caused by the spirochete Borrelia burgdorferi. Therefore, it should come as no surprise that their opinions would clash with the IDSA's (...) evidence-based guidelines for the diagnosis and treatment of Lyme disease. Their allegations of conflict of interest against the IDSA resemble those made against the National Institutes of Health, the Food and Drug Administration and the Centers for Disease Control and Prevention in 2000, which were found to be baseless. It is the responsibility of all physicians and medical scientists to stand up to antiscientific, baseless and unethical attacks on those who support an evidence-based approach to caring for patients. (shrink)

Three questions motivate this book's account of evidence for the existence of God. First, if God's existence is hidden, why suppose He exists at all? Second, if God exists, why is He hidden, particularly if God seeks to communicate with people? Third, what are the implications of divine hiddenness for philosophy, theology, and religion's supposed knowledge of God? This book answers these questions on the basis of a new account of evidence and knowledge of divine reality that challenges skepticism about (...) God's existence. The central thesis is that we should expect evidence of divine reality to be purposively available to humans, that is, available only in a manner suitable to divine purposes in self-revelation. This lesson generates a seismic shift in our understanding of evidence and knowledge of divine reality. The result is a needed reorienting of religious epistemology to accommodate the character and purposes of an authoritative, perfectly loving God. (shrink)

In 1990, the Federal Trade Commission (FTC) issued a consent order to the American Institute of Certified Public Accountants (AICPA). The order decreed the AICPA to lessen its longstanding ethics code which had until then banned the receipts of commissions, referral fees and contingent fees. The FTC alleged that the AICPA banned receipt of the fees as an attempt to restrain trade (FTC, 1990).In the present study, we sought to determine if CPAs'' preference for bans on commissions, referral fees and (...) contingent fees is related to their moral reasoning whereby CPAs perceive the bans to serve as a means of resolving ethical issues. While determining this matter cannot prove whether the bans did or did not actually result in restrained trade, it can offer insight into the perceived ethical importance to CPAs of the overturned rules. Based on a random sample of AICPA members and using Rest''s Defining Issues Test (DIT) to measure moral reasoning, we did not find a CPA''s moral reasoning to be related to his/her preference for ethics rules which ban commissions, referral fees or contingent fees. However, our results did indicate that most CPAs prefer banning commissions, referral fees and contingent fees, with those CPAs holding a higher financial stake in public accounting, namely partners, favoring banning referral fees and contingent fees significantly less than CPAs with a lesser stake. Further, we noted a significant negative relationship between financial stake and moral reasoning. These results seem to suggest that self-interest among CPAs may influence their moral reasoning.Further study is needed to examine the relationship between self-interest of CPAs and their moral reasoning. If self-interest clouds moral judgments made by CPAs, capital markets are in danger. Rendering an independent audit opinion must exclude self-interest. (shrink)

Suppose some person 'A' sets out to accomplish a difficult, long-term goal such as writing a passable Ph.D. thesis. What should you believe about whether A will succeed? The default answer is that you should believe whatever the total accessible evidence concerning A's abilities, circumstances, capacity for self-discipline, and so forth supports. But could it be that what you should believe depends in part on the relationship you have with A? We argue that it does, in the case where A (...) is yourself. The capacity for "grit" involves a kind of epistemic resilience in the face of evidence suggesting that one might fail, and this makes it rational to respond to the relevant evidence differently when you are the agent in question. We then explore whether similar arguments extend to the case of "believing in" our significant others -- our friends, lovers, family members, colleagues, patients, and students. (shrink)

Past, present, and future are reversed in the reader's encounter with the illustrations selected by Gertrude Stein for her Autobiography of Alice B. Toklas.1 After the table of contents there is a table of illustrations that encourages everyone to look at the pictures before they begin reading. During that initial examination, the illustrations forecast what is to be discovered in the text. Expectations are aroused by photographs showing Gertrude Stein in front of the atelier door, rooms hung with paintings, Gertrude (...) and Alice in front of Saint Mark's Cathedral, and both with a car in front of Joffre's birthplace. It is natural—although, as it turns out, not altogether correct—to assume that the accumulation of paintings will be explained, that the life lived within the rooms will be fully depicted, and that conventional narrative explanation will be provided to account for the presence of Gertrude and Alice together in such disparate settings as Venice and the French marshal's home. · 1. For useful comments on several pictures as well as evidence that "even the book's sixteen photographs were carefully placed in the first edition," see Richard Bridgman, Gertrude Stein in Pieces , p. 219. Paul K. Alkon, professor of English at the University of Minnesota, is author of Samuel Johnson and Moral Discipline. Among his recent articles are "Boswellian Time" and "The Historical Development of the Concept of Time." He is writing a book about time in Defoe's fiction. See also: "The Mind, The Body, and Gertrude Stein" by Catharine R. Stimpson in Vol. 3, No. 3; "Gertrude Stein, the Cone Sisters, and the Puzzle of Female Friendship" by Carolyn Burke in Vol. 8, No. 3. (shrink)

If God exists, where can we find adequate evidence for God's existence? In this book, Paul Moser offers a new perspective on the evidence for God that centers on a morally robust version of theism that is cognitively resilient. The resulting evidence for God is not speculative, abstract, or casual. Rather, it is morally and existentially challenging to humans, as they themselves responsively and willingly become evidence of God's reality in receiving and reflecting God's moral character for others. Moser (...) calls this 'personifying evidence of God,' because it requires the evidence to be personified in an intentional agent - such as a human - and thereby to be inherent evidence of an intentional agent. Contrasting this approach with skepticism, scientific naturalism, fideism, and natural theology, Moser also grapples with the potential problems of divine hiddenness, religious diversity, and vast evil. (shrink)

Many philosophers are again examining the traditional topic of a priori knowledge, or knowledge that does not depend on sensory experience. This volume collects the most important recent essays on the subject by well-known thinkers such as A.J. Ayer, W.V. Quine, Barry Stroud, C.I. Lewis, Hilary Putnam, Roderick M. Chisholm, Saul A. Kripke, Albert Casullo, R.G. Swinburne, and Philip Kitcher. Including an introduction by the editor and an extensive bibliography, this book provides philosophers and students with an in-depth look at (...) contemporary investigations into the nature of a priori knowledge. (shrink)

G.E.M. Anscombe famously claimed that acting intentionally entails knowing "without observation" what one is doing. Among those that have taken her claim seriously, an influential response has been to suppose that in order to explain this fact, we should conclude that intentions are a species of belief. This paper argues that there are good reasons to reject this "cognitivist" view of intention in favor of the view that intentions are distinctively practical attitudes that are not beliefs and do not constitutively (...) involve the belief that one will do what one intends. A theory is then proposed on behalf of Distinctive Practical Attitude views of intention to explain Anscombe's non-observational knowledge phenomenon. It is argued that intentions do not embody non-observational knowledge, but they do provide the evidential basis for it: we know without observation what we are doing by inferring from our intentions. (shrink)

The Socratic, or dialog, form is central to the history of philosophy and has been the discipline's canonical genre ever since. Paul Feyerabend's Three Dialogues on Knowledge resurrects the form to provide an astonishingly flexible and invigorating analysis of epistemological, ethical and metaphysical problems. He uses literary strategies - of irony, voice and distance - to make profoundly philosophical points about the epistemic, existential and political aspects of common sense and scientific knowledge. He writes about ancient and modern relativism; (...) the authority of science; the ignorance of scientists; the nature of being; and true and false enlightenment. Throughout Three Dialogues on Knowledge is provocative, controversial and inspiring. It is, unlike most current philosophical writing, written for readers with a keen sense of what matters and why. (shrink)

DNA double‐strand breaks (DSBs) are extremely hazardous lesions for all DNA‐bearing organisms and the mechanisms of DSB repair are highly conserved. In the eukaryotic mitotic cell cycle, DSBs are often present following DNA replication while, in meiosis, hundreds of DSBs are generated as a prelude to the reshuffling of the maternally and paternally derived genomes. In both cases, the DSBs are repaired by a process called homologous recombinational repair (HRR), which utilises an intact DNA molecule as the repair template. Mitotic (...) and meiotic HRR are managed by ‘checkpoints’ that inhibit cell division until DSB repair is complete. Here we attempt to summarise the substantial recent progress in understanding the checkpoint management of HRR in mitosis (focussing mainly on mammals) and then go on to use this information as a framework for understanding the presumed checkpoint management of HRR in mammalian meiosis. BioEssays 29:974–986, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Profielen van twaalf structuralistische en post-structuralistische Franse filosofen.

This book explores the role of divine severity in the character and wisdom of God, and the flux and difficulties of human life in relation to divine salvation. Much has been written on problems of evil, but the matter of divine severity has received relatively little attention. Paul K. Moser discusses the function of philosophy, evidence and miracles in approaching God. He argues that if God's aim is to extend without coercion His lasting life to humans, then commitment to (...) that goal could manifest itself in making human life severe, for the sake of encouraging humans to enter into that cooperative good life. In this scenario, divine agapē is conferred as free gift, but the human reception of it includes stress and struggle in the face of conflicting powers and priorities. Moser's work will be of great interest to students of the philosophy of religion, and theology. (shrink)

Contains nineteen newly commissioned articles by top philosophers on various aspects of the theory of knowledge. The articles survey the field as well as make original contributions to contemporary debates.

There is a puzzle about how to understand the conclusion of a successful instance of practical reasoning. Do the considerations adduced in reasoning rationalize the particular doing of an action, as Aristotle is sometimes interpreted as claiming? Or does reasoning conclude in the formation of an attitude – an intention, say – that has an action-type as its content? This paper attempts to clarify what is at stake in that debate and defends the latter view against some of its critics.

Rhodopsin, upon activation by light, transduces the photon signal by activation of the G‐protein, transducin. The well‐studied rhodopsin/transducin system serves as a model for the understanding of signal transduction by the large class of G‐protein‐coupled receptors. The interactive form of rhodopsin, R*, is conformationally similar or identical to rhodopsin's photolysis intermediate Metarhodopsin II (MII). Formation of MII requires deprotonation of rhodopsin's protonated Schiff base which appears to facilitate some opening of the rhodopsin structure. This allows a change in conformation at (...) rhodopsin's cytoplasmic surface that provides binding sites for transducin. Rhodopsin's 2nd, 3rd and putative 4th cytoplasmic loops bind transducin at sites including transducin's 5 kDa carboxyl‐terminal region. Site‐specific mutagenesis of rhodopsin is being used to distinguish sites on rhodopsin's surface that are important in binding transducin from those that function in activating transducin. These observations are consistent with and extend studies on the action of other G‐protein‐coupled receptors and their interactions with their respective G proteins. (shrink)

How do we know what our intentions are? It is argued that work on self-knowledge has tended to neglect the attitude of intention, and that an epistemological account is needed that is attuned to the specific features of that state. Richard Moran’s Authorship view, on which we can acquire self-knowledge by making up our minds, offers a promising insight for such an account: we do not normally discover what we intend through introspection. However, his formulation of the Authorship view, developed (...) primarily with the attitude of belief in mind, is found wanting when applied to intention. An alternative account is proposed for knowledge of one’s own intentions that gives a central role to the mental act of deciding what to do. It is argued that we can come to know what we intend by making a decision about what to do and self-ascribing the content of that decision as our intended action. (shrink)